Summary
Published in Communications Biology (2023), this peer-reviewed study used 3D Petri Dish® micro-molds to form scaffold-free 3D microtissues. Full citation: Steinberg, Eliana, et al. A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine
Research Overview
Reliable ex vivo tumor models could make drug screening precise enough for patient-targeted therapy, and microfluidic tumor-on-chip technology is the emerging preferred tool because it recreates the physical microenvironment of tumors.
To overcome the usual obstacles of the technology, this study developed a fully 3D-printed device that sustains patient-derived multicellular spheroids long enough to run multiple drug screening tests. The tool is cost-effective and combines the necessary characteristics for repeated multi-drug testing on the same patient-derived material.
Key Discoveries
- Fully 3D-printed tumor-on-chip device sustains patient-derived spheroids for repeated testing
- Enables multi-drug screening on the same patient material
- Cost-effective design addresses common barriers to microfluidic tumor models
