Summary
Published in Drug Delivery and Translational Research (2022), this peer-reviewed study used 3D Petri Dish® micro-molds to form scaffold-free 3D microtissues. Full citation: Esa, Rawnaq, et al. Newly synthesized methionine aminopeptidase 2 inhibitor hinders tumor growth
Newly synthesized methionine aminopeptidase 2 inhibitor hinders tumor growth
Research Overview
Inhibiting methionine aminopeptidase 2 is a recognized strategy for suppressing angiogenesis and cancer progression. This study synthesized small-molecule fumagillol derivatives carrying adamantane side groups and evaluated them for inhibitory activity, identifying a lead compound designated AD-3281.
AD-3281 effectively suppressed proliferation of both cancer and endothelial cells and impaired endothelial tube formation in vitro. Administered systemically, it was well tolerated and significantly suppressed human melanoma and mammary tumor xenografts.
Key Discoveries
- Lead fumagillol derivative AD-3281 showed superior methionine aminopeptidase 2 inhibition
- Suppressed cancer and endothelial cell proliferation and impaired tube formation in vitro
- Well tolerated systemically with significant suppression of melanoma and mammary xenografts
