Summary
Published in Cell Death Discovery (2023), this publication cites the 3D Petri Dish® micro-mold system rather than reporting its own experimental use of it. Full citation: Tian, Cheng-mei, et al. Stem cell-derived intestinal organoids: a novel modality for IBD
Stem cell-derived intestinal organoids: a novel modality for IBD
Research Overview
Organoids are among the past decade’s major biomedical advances: 3D micro-organs grown in vitro whose structure closely resembles native tissue. Built from the regenerative capacity of stem cells, intestinal organoids reproduce the morphology, function, and individualized stimulus responses of the real intestine.
This review discusses stem-cell-based 3D intestinal models across their uses — dissecting molecular pathophysiology, high-throughput drug screening, efficacy and toxicology testing, and organ-based regeneration for inflammatory bowel disease — and summarizes the advances, limitations, and open challenges of current reconstruction platforms.
Key Discoveries
- Reviews stem-cell-derived intestinal organoids as models of morphology, function, and personalized response
- Covers applications from pathophysiology and drug screening to toxicology and IBD regeneration
- Assesses advances and limitations of current organoid reconstruction platforms
