Summary
Published in J Controlled Release (2022) DOI: doi.org/10.1016/j.jconrel.2022.07.029 (2022), this study utilized 3D Petri Dish® micro-molds to generate uniform microtissues for investigating orla delivery of camptothecin-loaded multifunctional chitosan- based micells is effective to reduce colorectal cancer. j controlled release (2022) doi: doi.org/10.1016/j.jconrel.2022.07.029. The research demonstrates the value of standardized 3D cell culture models in advancing our understanding of this field.
Orla delivery of camptothecin-loaded multifunctional chitosan- based micells is effective to reduce colorectal cancer. J Controlled Release (2022) DOI: doi.org/10.1016/j.jconrel.2022.07.029
3D Petri Dish® Application
Frequently Asked Questions
Can 3D spheroids be used for drug screening?
Yes, 3D tumor spheroids created with 3D Petri Dish® micro-molds are widely used for high-throughput drug screening. The uniform size and reproducibility of the spheroids enables reliable dose-response measurements and comparison across experimental conditions.
Why are 3D microtissues better than traditional 2D cell cultures?
3D microtissues formed using 3D Petri Dish® micro-molds better recapitulate the complex cell-cell interactions, extracellular matrix organization, and signaling gradients found in living tissues. This leads to more physiologically relevant results compared to growing cells on flat plastic surfaces, where cells often behave differently than they do in the body.