Summary
Published in International Journal of Molecular Sciences (2018), this publication cites the 3D Petri Dish® micro-mold system rather than reporting its own experimental use of it. Full citation: Zhu, Sheng, et al. From the Clinical Problem to the Basic Research—Co-Culture Models of Osteoblasts and Osteoclasts
From the Clinical Problem to the Basic Research—Co-Culture Models of Osteoblasts and Osteoclasts
Research Overview
Bone constantly remodels and heals after fracture to preserve its structural integrity, and bone cell co-culture technology is expected to shed light on open biological and clinical questions in bone disease. Osteoblasts/osteocytes and osteoclasts dominate bone metabolism through a multitude of connections between them.
There is broad agreement that co-culture models with both cell types grown on a 3D scaffold should be improved continuously to approach the in vivo environment as closely as possible. This review summarizes the current knowledge on bone co-culture models accumulated in recent years and addresses the questions that remain open.
Key Discoveries
- Reviews osteoblast/osteocyte-osteoclast co-culture models for bone research
- Emphasizes 3D scaffold-based co-culture to mimic the in vivo bone environment
- Summarizes accumulated knowledge and frames remaining open questions
